![]() The diagnosis of Cushing's syndrome is based on clinical suspicion combined with a review of the patient’s medical history, physical examination and laboratory tests to help determine the existence of excessive levels of cortisol. ![]() Cortisol production is regulated by the ACTH produced in the pituitary gland. It mobilizes nutrients, modifies the body's response to inflammation, stimulates the liver to raise blood sugar and helps control the amount of water in the body. When functioning correctly, cortisol helps the body respond to stress and change. ![]() ![]() These effects together are known as Cushing's syndrome.Ĭushing’s syndrome can be caused by overuse of cortisol medication, as seen in the treatment of chronic asthma or rheumatoid arthritis ( iatrogenic Cushing’s syndrome), excess production of cortisol from a tumor in the adrenal gland or elsewhere in the body ( ectopic Cushing’s syndrome) or a tumor of the pituitary gland secreting adrenocorticotropic hormone (ACTH) which stimulates the over-production of cortisol from the adrenal gland (Cushing’s disease).Ĭortisol is a normal hormone produced in the outer portion of the adrenal glands. Cortisol affects all tissues and organs in the body. Cushing's syndrome is a disorder caused by the body’s exposure to an excess of the hormone cortisol.
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